STD Home > Side Effects of Etravirine

In clinical studies, the most common side effects of etravirine (when used with other HIV medications) included a rash and unusual sensations in the hands or feet. Other, less common problems (occurring in less than 2 percent of people) included constipation, dry mouth, and blurred vision. While most side effects are minor, you should seek medical attention immediately if you develop frequent infections or any allergic reactions.

Etravirine Side Effects: An Introduction

As with any medicine, side effects are possible with etravirine (Intelence®); however, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. When side effects do occur, in most cases they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with etravirine. Your healthcare provider can discuss a more complete list of etravirine side effects with you.)

Side Effects to Report

There are a number of etravirine side effects that you should report to your healthcare provider. These include, but are not limited to:
  • Changes in the distribution of fat on your body (such as increased fat in the upper back area, known as a "buffalo hump")
  • Yellowing of the skin or whites of the eyes, dark urine, or pain on the right side of abdomen (stomach)
  • Allergic reactions (see below). 
Etravirine and Allergic Reactions
Etravirine can cause very serious (sometimes life-threatening) allergic reactions, particularly dangerous skin rashes. While harmless skin rashes are quite common with etravirine, you should stop taking etravirine and contact your healthcare provider right away if you develop a rash with any of the following symptoms:
  • Blisters
  • Loss of skin
  • Fever
  • Sores in the mouth
  • Difficulty breathing or swallowing
  • Swelling of your face, eyes, lips, or mouth.
These allergic reactions can become quite dangerous, causing severe infections, loss of significant portions of the skin, or even organ failure (such as liver failure).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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