STD Home > Drug Interactions With Enskyce

A number of products, such as St. John's wort, cyclosporine, and certain antibiotics, may cause drug interactions with Enskyce. Some of these combinations can decrease the effectiveness of Enskyce, possibly increasing the chance of unintentional pregnancy. To avoid these and other complications, tell your healthcare provider about all other products you are taking, including vitamins, herbal supplements, and nonprescription medications.

An Introduction to Enskyce Interactions

Enskyce™ (desogestrel/ethinyl estradiol) is an oral contraceptive that is a generic version of Desogen® and Ortho-Cept®. Enskyce can potentially interact with several other medicines. Many of these interactions can be severe enough to cause accidental pregnancy, and a backup method of birth control may be recommended to avoid pregnancy. Some of the medicines that may react negatively with Enskyce include:
  • Aminoglutethimide (Cytadren®)
  • Antibiotics
  • Aprepitant (Emend®)
  • Atorvastatin (Lipitor®) or combination medications that contain atorvastatin (Caduet®, Liptruzet™)
  • Barbiturate medications, such as:
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®
(Enskyce is equivalent to Desogen, Ortho-Cept, Apri®, Emoquette™, Solia™, and Reclipsenbirth control pills. The information in this article also applies to each of these medications.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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