STD Home > Depo-Provera Dosage

Your particular dosing guidelines with Depo-Provera will depend on why you are using this drug and how you respond to it, among other factors. The standard dose for preventing pregnancy with this medicine is 150 mg injected every 13 weeks. For relieving kidney and endometrial cancer symptoms, 400 mg to 1000 mg each week is typically used initially.

An Introduction to Dosing With Depo-Provera

The dosage of Depo-Provera® (medroxyprogesterone intramuscular injection) your healthcare provider recommends will vary, depending on a number of factors, including:
  • The reason you are receiving Depo-Provera
  • How you respond to the medication.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Depo-Provera Dosage for Pregnancy Prevention

The standard dose of Depo-Provera for preventing pregnancy is 150 mg every 3 months (13 weeks). The first injection should only be given at a time when pregnancy is not a possibility. These times include:
  • The first five days of the menstrual period
  • The first five days after birth in women who are not breastfeeding
  • The sixth week after birth in women who are breastfeeding.
Depo-Provera is most effective if given every 13 weeks. If more than 13 weeks have passed since the last shot, pregnancy should be ruled out again before another Depo-Provera dose is given.
If you are switching from oral contraceptives to Depo-Provera, you should receive your first shot after taking your last active pill, but before you take your last inactive pill. If you are switching from another form of birth control to Depo-Provera, your healthcare provider will determine when you should receive your first shot to ensure you have continuous birth control coverage.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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