STD Home > More Info on Delavirdine Interactions

Rifabutin or Rifampin
Taking delavirdine with rifabutin or rifampin can make delavirdine less effective. Delavirdine should not be used with these medications.
Delavirdine can increase the level of sildenafil in your blood, possibly increasing your risk of side effects. If you are taking delavirdine, you should not take more than 25 mg of sildenafil in 48 hours.
Some Statin Medications
Delavirdine should never be used with lovastatin or simvastatin due to the risk of dangerous reactions. Combining delavirdine with other statin medications can increase the level of the statin in your blood. Your healthcare provider may need to lower your statin dose to prevent this.
St. John's Wort
Because St. John's wort can make delavirdine less effective, people taking delavirdine should not take St. John's wort.
Delavirdine may increase the level of tacrolimus in your blood. Your healthcare provider may recommend a lower tacrolimus dosage to prevent this interaction from occurring.
Trazodone (Desyrel) or Trazodone ER (Oleptro) 
Delavirdine may increase the level of trazodone in your blood. Your healthcare provider may recommend a lower trazodone dosage to prevent this.
Delavirdine can interact unpredictably with warfarin. Your healthcare provider may need to monitor you more closely while you are taking these two medications.

Final Thoughts on Drug Interactions With Delavirdine

It is possible that not all drug interactions with delavirdine were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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