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Common Side Effects of Darunavir

Clinical studies have not evaluated darunavir alone for the treatment of HIV, since it is meant to be used along with other HIV medications. In fact, the available information on side effects involves studies that used darunavir plus one or two other HIV medications. Therefore, it is difficult to determine whether these side effects are caused by darunavir or the other HIV medications.
Based on these studies, the most common side effects of darunavir (plus one or two other HIV medications) included:
  • High triglycerides -- in up to 25.4 percent of people
  • Diarrhea -- up to 19 percent
  • Vomiting -- up to 14 percent
  • Abdominal pain (stomach pain) -- up to 10 percent
  • Rash -- up to 10 percent
  • Headaches -- up to 9 percent
  • High cholesterol -- up to 9.2 percent
  • Nausea -- up to 4 percent
  • Fatigue -- up to 3 percent 
  • Constipation -- up to 2.3 percent.

Less Common Side Effects of Darunavir

Rare side effects of darunavir occur in less than 2 percent of people taking the drug. Because these side effects are so uncommon, it is difficult to determine if they are actually caused by darunavir or something else.
These less common side effects include but are not limited to:
  • Fever
  • Fatigue
  • Water retention in the calves, ankles, or feet
  • High blood pressure (hypertension)
  • Gas
  • Dry mouth
  • Indigestion or heartburn
  • Nausea
  • Osteoporosis
  • Drowsiness
  • Unusual sensations (like burning, tingling, or numbness) in the hands or feet
  • Eczema
  • Increased sweating
  • A spinning sensation (vertigo).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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