STD Home > More Medications That Interfere With Darunavir

Certain Other Protease Inhibitors
Combining darunavir with certain other protease inhibitors can increase or decrease the level of both medications in your blood. Check with your healthcare provider before taking darunavir with another protease inhibitor.
 
Colchicine
Darunavir may increase the level of colchicine in your blood. Your healthcare provider may need to lower your colchicine dosage while you are taking darunavir.
  
Dexamethasone
Dexamethasone can decrease the level of darunavir in your blood. Check with your healthcare provider before combining these two medications.
 
Didanosine
Darunavir and didanosine products should not be taken at the same time, since darunavir should be taken with food and didanosine should be taken on an empty stomach. Be sure to take these products at different times of the day.
 
Efavirenz
Combining efavirenz with darunavir can increase the level of efavirenz and decrease the level of darunavir in your blood. Your healthcare provider may need to adjust your dose of these medications to prevent drug interactions from occurring.
 
Ergot Medications
Darunavir should not be combined with ergot medications, due to the risk of dangerous side effects.
 
Fluticasone or Combination Medications That Contain Fluticasone
Darunavir may increase the level of fluticasone in your blood. Check with your healthcare provider before taking these medications together.
 
Immune-Suppressing Medications
Darunavir may increase the level of some immune-suppressing medications in your blood. Your healthcare provider may need to decrease the dose of your immune-suppressing medication to prevent this interaction from occurring.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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