STD Home > Other Medications That Interact With Atazanavir

Proton Pump Inhibitors
PPIs can decrease the level of atazanavir in your blood, potentially making it less effective. You may (or may not) be able to combine a PPI with atazanavir, depending on several factors (see Atazanavir Dosing).
Combining salmeterol with atazanavir may increase the risk of serious side effects of salmeterol (especially heart problems). Check with your healthcare provider before combining such medications. In general, these medications should not be combined.
Seizure Medications
Some seizure medications can decrease the level of atazanavir in your blood, perhaps making it less effective. Check with your healthcare provider before taking atazanavir with a seizure medication.
Additionally, atazanavir can also affect the level of the seizure medication in the bloodstream, making it higher (for carbamazepine) or lower (for phenytoin, phenobarbital, or lamotrigine). Check with your healthcare provider before combining these medications.
Some Statin Medications
Atazanavir should never be combined with lovastatin or simvastatin, due to the risk of dangerous side effects. Since atazanavir may increase the level of atorvastatin or rosuvastatin in your blood, your healthcare provider may recommend a lower atorvastatin or rosuvastatin dosage to prevent this interaction from occurring.
St. John's Wort
Because St. John's wort can greatly reduce the level of atazanavir in your blood, these medications should never be taken together.
Taking tenofovir with atazanavir can increase the level of tenofovir and decrease the level of atazanavir in your blood. This combination of medications should always be used along with ritonavir (Norvir®) to increase the level of atazanavir in the blood, and higher atazanavir dosing may be recommended.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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