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Common and Rare Reactions to Lopinavir and Ritonavir

Common Side Effects of Lopinavir and Ritonavir

Clinical studies have not evaluated lopinavir and ritonavir alone for the treatment of HIV, since it is meant to be used along with other HIV medications. In fact, the available information on side effects involves studies that used lopinavir and ritonavir with two or three other HIV medications. Therefore, it is difficult to know whether these side effects are actually due to lopinavir and ritonavir or the other medications.
 
In these studies, the most common side effects of lopinavir and ritonavir (in combination with other HIV medications) included:
 
  • Diarrhea -- in up to 27 percent of people
  • Nausea -- up to 16 percent
  • Abdominal pain (stomach pain) -- up to 10 percent
  • Weakness -- up to 9 percent
  • Headaches -- up to 7 percent
  • Vomiting -- up to 6 percent
  • Indigestion or heartburn -- up to 5 percent
  • Missed menstrual periods -- up to 4.5 percent
  • Gas -- up to 4 percent.
     
Other common side effects (occurring in up to 2 percent of people) included:
 

Less Common Side Effects of Lopinavir and Ritonavir

Rare lopinavir and ritonavir side effects occur in less than 2 percent of people taking the drug (along with other HIV medications). Because these side effects are so uncommon, it is difficult to determine whether they are actually caused by the medication or something else.
 
These less common side effects include but are not limited to:
 

Lopinavir and Ritonavir for HIV/AIDS

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