Drug Interactions With Lopinavir and Ritonavir

Dexamethasone, metronidazole, and trazodone are some of the medications that may cause drug interactions with lopinavir and ritonavir. These interactions can increase your risk for potentially serious side effects or decrease the effectiveness of the medications. Other medicines that may cause drug interactions with lopinavir and ritonavir include atovaquone, efavirenz, immune-suppressing medications, and certain benzodiazepines.

 

Drug Interactions With Lopinavir and Ritonavir: An Introduction

Lopinavir and ritonavir (Kaletra®) can potentially interact with several other medicines. Some of the medicines that may lead to lopinavir and ritonavir drug interactions include:
 
  • Arrhythmia medications
  • Atovaquone (Mepron®)
  • Certain antibiotics and antifungal medications, such as:
 
    • Clarithromycin (Biaxin®)
    • Ketoconazole (Nizoral®)
    • Itraconazole (Sporanox®)
    • Rifabutin (Mycobutin®)
    • Rifampin (Rifadin®)
    • Voriconazole (Vfend®)
 
  • Certain benzodiazepines, such as:
 
 
 
 
 
 
  • Ergot medications, such as:
 
    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergonovine
    • Ergotamine (Bellamine S®, Cafergot®, Ergomar®)
    • Methylergonovine (Methergine®)
    • Pergolide (Permax®)
 
  • Fluticasone (Flonase®, Flovent®, Veramyst®) or combination medications that contain fluticasone (Advair®)
  • Immune-suppressing medications, such as:
 
    • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
    • Sirolimus (Rapamune®)
    • Tacrolimus (Prograf®)
 
  • Hormonal contraceptives (birth control pills, patches, or rings)
  • Methadone (Dolophine®, Methadose®)
  • Metronidazole (Flagyl®)
  • Nevirapine (Viramune®)
  • Other protease inhibitors, such as:
 
 
  • Pimozide (Orap®)
  • Rifampin (Rifadin®) 
  • Seizure medications
  • Some statin medications, such as:
 
 
(Drug Interactions With Lopinavir and Ritonavir Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;