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Drug Interactions With Lopinavir and Ritonavir

Dexamethasone, metronidazole, and trazodone are some of the medications that may cause drug interactions with lopinavir and ritonavir. These interactions can increase your risk for potentially serious side effects or decrease the effectiveness of the medications. Other medicines that may cause drug interactions with lopinavir and ritonavir include atovaquone, efavirenz, immune-suppressing medications, and certain benzodiazepines.

Drug Interactions With Lopinavir and Ritonavir: An Introduction

Lopinavir and ritonavir (Kaletra®) can potentially interact with several other medicines. Some of the medicines that may lead to lopinavir and ritonavir drug interactions include:


  • Certain antibiotics and antifungal medications, such as:
  • Certain benzodiazepines, such as:


  • Certain chemotherapy drugs, such as:


    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergonovine
    • Ergotamine (Bellamine S®, Cafergot®, Ergomar®)
    • Methylergonovine (Methergine®)
    • Pergolide (Permax®)




  • Phosphodiesterase type 5 inhibitors (PDE5 inhibitors), including:


  • Some statin medications, such as:


Lopinavir and Ritonavir for HIV/AIDS

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