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Will My Medicines React With Lopinavir and Ritonavir?

Some Statin Medications
Lopinavir and ritonavir should never be combined with lovastatin or simvastatin, due to the risk of dangerous side effects. Since lopinavir and ritonavir may increase the level of atorvastatin or rosuvastatin in your blood, your healthcare provider may recommend a lower rosuvastatin or atorvastatin dosage.
St. John's Wort
Because St. John's wort can greatly reduce the level of lopinavir and ritonavir in your blood, these substances should never be taken together.
Lopinavir and ritonavir can increase the level of tenofovir in your blood. Your healthcare provider may need to lower your tenofovir dosage to prevent this interaction from occurring.
Trazodone (Desyrel) or Trazodone ER (Oleptro) 
Lopinavir and ritonavir can increase the level of trazodone in your blood. Check with your healthcare provider before taking these medications together.

Final Thoughts on Drug Interactions With Lopinavir and Ritonavir

It is possible that not all drug interactions with lopinavir and ritonavir were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific drug interactions that may apply to you.

Lopinavir and Ritonavir for HIV/AIDS

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