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More Details on Drug Interactions With Lopinavir and Ritonavir

Efavirenz
Efavirenz can lower the level of lopinavir and ritonavir in your blood, perhaps making it less effective. Your healthcare provider may need to increase your lopinavir and ritonavir dosage. When used in combination with efavirenz, once-daily dosing with lopinavir and ritonavir is not recommended (it should be taken twice a day instead).
 
Ergot Medications
Lopinavir and ritonavir should not be combined with ergot medications, due to the risk of dangerous side effects.
 
Fentanyl
Lopinavir and ritonavir may increase the level of fentanyl in the blood, increasing the risk of fentanyl side effects, including potentially fatal problems. Check with your healthcare provider before taking these medications together.
  
Fluticasone or Combination Medications That Contain Fluticasone
Lopinavir and ritonavir may increase the level of fluticasone in your blood. Check with your healthcare provider before taking these medications together. In general, these medications should not be combined unless absolutely necessary.
 
Immune-Suppressing Medications
Lopinavir and ritonavir may increase the level of some immune-suppressing medications in your blood. Your healthcare provider may need to decrease the dose of your immune-suppressing medication to prevent this.
 
Hormonal Contraceptives
Lopinavir and ritonavir may make hormonal contraceptives less effective, possibly increasing the risk of pregnancy. You should use a non-hormonal method of contraception (such as condoms) while taking lopinavir and ritonavir.
 
Maraviroc
Lopinavir and ritonavir may increase the level of maraviroc in your blood. Your healthcare provider may need to decrease your maraviroc dosage.
 
Medications That Prolong the QT Interval
Lopinavir and ritonavir can cause a potentially dangerous irregular heart rhythm known as QT prolongation. It may not be recommended to combine lopinavir and ritonavir with other QT-prolonging medications.
  
Methadone
Lopinavir and ritonavir may decrease the level of methadone in your blood, perhaps making it less effective. Your healthcare provider may need to increase your methadone dosage as a result.

Lopinavir and Ritonavir for HIV/AIDS

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