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Loestrin Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Loestrin is combined with any of the drugs listed above. If you are unsure about any particular interaction, it is a good idea to use backup birth control until you can speak with your healthcare provider.
 
Aminoglutethimide (Cytadren)
Taking Loestrin with aminoglutethimide may increase your risk of unintentional pregnancy. Talk with your healthcare provider before using these medications together. You may need to use a backup method of contraception, such as condoms.
 
Antibiotics
There have been reports of accidental pregnancy occurring in women taking birth control pills with certain antibiotics. However, it is still uncertain how significant this interaction may be. Some antibiotics are more likely to cause problems than others. Ask your healthcare provider if you need a backup method of contraception any time you take an antibiotic.
 
Aprepitant (Emend)
Aprepitant may make Loestrin less effective, perhaps increasing your chance of pregnancy. Talk with your healthcare provider before using these medications together. You may need to use a backup method of contraception.
 
Barbiturates
Barbiturates may cause your body to metabolize the hormones in Loestrin too quickly, possibly increasing your risk of pregnancy. Ask your healthcare provider if you should use a different method of contraception while taking a barbiturate.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
Loestrin may increase the level of cyclosporine in your blood, possibly increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. Your cyclosporine dose may need to be reduced, or you may need to switch to a different method of contraception.
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