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Precautions and Warnings With Indinavir

Talk to your healthcare provider about the precautions and warnings with indinavir before taking the drug to help ensure a safe and effective treatment process. Also, be sure to let him or her know if you have hemophilia, diabetes, or kidney disease before starting treatment. It is important that you stay hydrated while taking indinavir because the medication frequently causes kidney stones.

Indinavir: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking indinavir sulfate (Crixivan®) if you have:
Also, let your healthcare provider know if you are:


  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also be sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Warnings and Precautions for Indinavir

Warnings and precautions to be aware of prior to taking indinavir include the following:
  • Indinavir frequently causes kidney stones. In order to help prevent kidney stones, you should stay hydrated while taking indinavir (drink at least six cups of fluids a day).
  • Indinavir can destroy red blood cells (this is known as hemolytic anemia). If you develop this problem while taking indinavir, your healthcare provider should recommend that you stop taking indinavir.
  • Indinavir can cause hepatitis (inflammation of the liver). Make sure to tell your healthcare provider if you already have liver disease or liver damage, as you may need a lower indinavir dosage.
  • Indinavir can cause high blood sugar (hyperglycemia). This can cause problems for people with diabetes or can even cause diabetes in individuals who are predisposed to the condition.
  • There have been reports of bleeding possibly due to protease inhibitors (such as indinavir) in people with hemophilia. Be sure your healthcare provider knows if you have hemophilia.
  • It is not known whether indinavir can safely be taken by people with kidney disease.
  • Indinavir can change the distribution of fat on your body. You may gain fat in areas that are not typical for you, such as in the abdomen or at the back of the neck (a "buffalo hump"), and may lose weight in other areas.
  • Indinavir is not a cure for HIV or AIDS. If you have HIV or AIDS, you should always use safer sex practices, regardless of whether you are taking medications.
  • As will all HIV medications, it is important that you take indinavir exactly as prescribed. Missing doses may increase the chance of the virus becoming resistant to HIV medications.
  • Indinavir can interact with a number of different medications (see Drug Interactions With Indinavir for more information).
  • Indinavir is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Crixivan and Pregnancy).
  • It is not known if indinavir passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Crixivan and Breastfeeding). It is important to understand that the HIV virus can be transmitted through breast milk and that breastfeeding is usually not recommended in women with HIV or AIDS.

Indinavir Sulfate for HIV/AIDS

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