Drug Interactions With Indinavir

There are a number of medications that may cause negative drug interactions with indinavir, including certain calcium channel blockers, benzodiazepines, and antibiotics or antifungals. While some interactions can reduce the effectiveness of the medicines, others can increase your risk for serious side effects. To minimize your chances of developing potentially dangerous indinavir interactions, let your healthcare provider know about all other medications you are taking.

 

Indinavir Drug Interactions: An Introduction

Indinavir sulfate (Crixivan®) can potentially interact with several other medicines. Some of these medicines that may lead to indinavir interactions include:
 
  • Certain antibiotics and antifungal medications, such as:

 

    • Clarithromycin (Biaxin®)
    • Ketoconazole (Nizoral®)
    • Itraconazole (Sporanox®)
    • Rifabutin (Mycobutin®)
    • Rifampin (Rifadin®)

 

  • Certain arrhythmia medications, including amiodarone (Cordarone®), lidocaine, and quinidine
     
  • Certain benzodiazepines, including:

 

 

 

 

 

 

  • Ergot medications, such as:

 

    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergonovine
    • Ergotamine (Bellamine S®, Cafergot®, Ergomar®)
    • Methylergonovine (Methergine®)
    • Pergolide (Permax®)

 

  • Fluticasone (Flonase®, Flovent®, Veramyst®) or combination medications that contain fluticasone (Advair®)
  • Immune-suppressing medications, including:

 

    • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
    • Sirolimus (Rapamune®)
    • Tacrolimus (Prograf®)

 

 

 

  • Pimozide (Orap®)
  • Seizure medications
  • Some statin medications, including:

 

 

(Drug Interactions With Indinavir Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;