Indinavir Drug Combinations to Avoid
Phosphodiesterase Type 5 Inhibitors (PDE5 Inhibitors)
Indinavir can increase the level of PDE5 inhibitors in your blood, increasing your risk of side effects. You should not take more than 25 mg of sildenafil (for erectile dysfunction treatment) in 48 hours, 10 mg of tadalafil (for erectile dysfunction treatment) in 72 hours, or 2.5 mg of vardenafil in 24 hours while taking indinavir.
At this time, it is recommended that if you take sildenafil for the purpose of treating pulmonary arterial hypertension, you should not take indinavir. When combining tadalafil for the purpose of treating pulmonary arterial hypertension with indinavir, the initial tadalafil dosage should be 20 mg once daily and may be adjusted up to 40 mg once daily as necessary and tolerated.
Combining salmeterol with indinavir may increase the risk of serious side effects of salmeterol, especially heart problems. Check with your healthcare provider before combining such medications. In general, these medications should not be combined.
Some seizure medications can decrease the level of indinavir in your blood, perhaps making it less effective. Check with your healthcare provider before taking indinavir with a seizure medication.
Some Statin Medications
Indinavir should never be combined with lovastatin or simvastatin, due to the risk of dangerous side effects. Since indinavir may increase the level of atorvastatin or rosuvastatin in your blood, your healthcare provider may recommend a lower rosuvastatin or atorvastatin dosage.
St. John's Wort
Because St. John's wort can greatly reduce the level of indinavir in your blood, these medications should never be taken together.