Drug Combinations With Etravirine to Avoid
Etravirine Drug Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when etravirine is combined with any of the drugs listed above.
Etravirine may decrease the level of buprenorphine in the blood. While this will usually cause no noticeable problems, it is possible that withdrawal symptoms from decreased buprenorphine levels) could occur. Your buprenorphine dosage may need to be adjusted.
Certain Antibiotics or Antifungals
Combining etravirine with certain antibiotics or antifungals may increase or decrease blood levels of etravirine and the antibiotic or antifungal (depending on the particular antibiotic or antifungal). If you take etravirine with one of these antibiotics or antifungal medications, your healthcare provider may need to adjust the dose of both of the medications. In some situations, an alternative antifungal or antibiotic may be recommended.
Certain Arrhythmia Medications
Etravirine can decrease the level of certain arrhythmia medications in the blood, perhaps making them less effective. Your healthcare may need to monitor your blood levels of the arrhythmia medication and adjust your dose as needed.
Etravirine can decrease the level of certain immunosuppressant medications in the blood, perhaps making them less effective. Your healthcare may need to monitor your blood levels of the immunosuppressant medication and adjust your dose as needed.
Certain Seizure Medications
Taking etravirine with certain seizure medications can decrease the level of etravirine in your blood, making it less effective. Etravirine should not be combined with carbamazepine, phenytoin, or phenobarbital.
Etravirine may decrease the activation of clopidogrel to its active form, perhaps making clopidogrel less effective. Your healthcare provider may want to consider recommending an alternative drug instead of clopidogrel if you take etravirine.
Dexamethasone can decrease the level of etravirine in your blood, perhaps making it less effective. Your healthcare provider may decide to use an alternative to dexamethasone.