Drug Interactions With Etonogestrel/Ethinyl Estradiol Vaginal Ring

Certain medications can cause negative drug interactions with etonogestrel/ethinyl estradiol vaginal ring that could lead to an increased risk for side effects and pregnancy. Be sure to tell your healthcare provider about all drugs you are taking before using the contraceptive. Medicines that may cause etonogestrel/ethinyl estradiol vaginal ring interactions include aprepitant, protease inhibitors, modafinil, and rifamycin antibiotics.

 

An Introduction to Etonogestrel/Ethinyl Estradiol Vaginal Ring Drug Interactions

Etonogestrel/ethinyl estradiol vaginal ring (NuvaRing®) can potentially interact with several other medicines. Some of these medicines that may lead to etonogestrel/ethinyl estradiol vaginal ring interactions include:
 
  • Aminoglutethimide (Cytadren®)
  • Aprepitant (Emend®)
  • Barbiturates, such as:

 

    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)

 

  • Certain seizure medications, such as:

 

 

  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
  • Griseofulvin (Grifulvin®)
  • Modafinil (Provigil®)
  • Nafcillin (Nallpen®, Unipen®)
  • Protease inhibitors, such as:

 

 

  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
  • Selegiline (Eldepryl®, Emsam®, Zelapar®)
  • St. Johns wort
  • Warfarin (Coumadin®, Jantoven®)
     
(Drug Interactions With Etonogestrel/Ethinyl Estradiol Vaginal Ring Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;