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What You Need to Know About Emtricitabine/Rilpivirine/Tenofovir

Drug Interactions

Emtricitabine/rilpivirine/tenofovir may react with a number of other medications (see Drug Interactions With Emtricitabine/Rilpivirine/Tenofovir).
 

What If I Overdose on This Medicine?

It is unknown what exactly to expect from an overdose of this medication. If you happen to take too much, seek immediate medical attention.
 
(Click Complera Overdose for more information.)
 

What If I Forget a Dose of Emtricitabine/Rilpivirine/Tenofovir?

It is important that you do not miss your doses. If you do not take your emtricitabine/rilpivirine/tenofovir as scheduled, take it as soon as possible, unless it is almost time for the next dose. In this case, simply skip the missed dose and continue with your regular schedule. Be sure to tell your healthcare provider if you are having trouble remembering to take your HIV medications.
 

How Does It Work?

This medication contains three different active ingredients. Tenofovir is a nucleotide reverse transcriptase inhibitor (NtRTI). Emtricitabine belongs to a group of medications known as nucleoside reverse transcriptase inhibitors (NRTIs). Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI).
 
HIV (human immunodeficiency virus) is the virus that causes AIDS. Like other viruses, HIV must use a person's own cells to reproduce. However, HIV is different from many other viruses because it must first convert its genetic material from RNA to DNA. It is the DNA genes that allow HIV to multiply.
 
HIV converts its genetic material by using a special protein called the reverse transcriptase enzyme. To create DNA, this enzyme uses several different protein building blocks.
 
Emtricitabine and tenofovir each work by tricking reverse transcriptase into thinking the drugs are actually one of these protein building blocks. However, emtricitabine and tenofovir are just different enough that when used to create DNA, they actually stop the DNA from being made. Rilpivirine works by attaching to the reverse transcriptase enzyme, stopping it from making DNA. Without DNA, HIV cannot multiply.
 
Emtricitabine/rilpivirine/tenofovir is not a cure for HIV or AIDS. Although it can help stop HIV from infecting healthy cells in the body, it does not help cells that have already been infected with the virus.
 

Emtricitabine/Rilpivirine/Tenofovir Information

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