Drug Interactions With Emtricitabine/Rilpivirine/Tenofovir

There are several medications that may cause negative drug interactions with emtricitabine/rilpivirine/tenofovir, including antacids, certain seizure medications, and methadone. Some of these reactions can decrease the absorption of emtricitabine/rilpivirine/tenofovir into the bloodstream, significantly reducing its effectiveness. Before starting treatment with this HIV medicine, let your healthcare provider know about all other medications, vitamins, and supplements you are taking.

An Overview of Emtricitabine/Rilpivirine/Tenofovir Interactions

 Emtricitabine/rilpivirine/tenofovir disoproxil fumarate (Complera™) can potentially interact with several other medications. Some of these products that may lead to reactions include:
 
  • Antacids, such as Tums® or Maalox®
  • Certain antibiotics and antifungal medications, such as:
 
 
  • Certain seizure medications, such as:
 
 
 
 
  • Methadone (Dolophine®, Methadose®)
  • Medications that cause a change in the heart rhythm known as QT prolongation (see QT-Prolonging Medications for a list)
  • Other non-nucleoside reverse transcriptase inhibitor (NNRTI) HIV medications, such as:
 
 
  • Proton pump inhibitors (PPIs), such as:
 
 
  • Rifabutin (Mycobutin®), rifampin (Rifadin®), or rifapentine (Priftin®)
  • St. John's wort.
 
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Written by/reviewed by: Kristi Monson, PharmD
Last reviewed by: Kristi Monson, PharmD
 
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