More Drugs That React With Emtricitabine/Rilpivirine/Tenofovir
Emtricitabine/rilpivirine/tenofovir can decrease the level of methadone in your blood, perhaps making it less effective. Your healthcare provider may need to increase your methadone dosage.
NSAIDs may interfere with the kidneys' ability to remove tenofovir from the blood. In addition, combining emtricitabine/rilpivirine/tenofovir with high doses of an NSAID or with multiple NSAIDs may increase the risk of kidney failure. It's best to check with your healthcare provider before combining emtricitabine/rilpivirine/tenofovir with any NSAID, including nonprescription ones.
Proton Pump Inhibitors (PPIs)
Emtricitabine/rilpivirine/tenofovir should never be combined with PPIs, as these medications can significantly decrease the effectiveness of emtricitabine/rilpivirine/tenofovir.
Several medications can cause a change in the heart rhythm known as QT prolongation, to varying degrees. If severe enough, this change can lead to a life-threatening arrhythmia known as torsades de pointes. Because emtricitabine/rilpivirine/tenofovir can cause QT prolongation, especially at higher-than-recommended dosages, it should be used cautiously in combination with other QT-prolonging drugs.
Emtricitabine/rilpivirine/tenofovir is an NNRTI and should not be combined with other NNRTIs.
Rifabutin, Rifampin, or Rifapentine
Emtricitabine/rilpivirine/tenofovir should never be combined with rifabutin, rifampin, or rifapentine, as these medications can significantly decrease the effectiveness of emtricitabine/rilpivirine/tenofovir.
St. John's Wort
Because St. John's wort can significantly decrease the level of emtricitabine/rilpivirine/tenofovir in your blood, these medications should never be taken together.