Drugs That Interfere With Emtricitabine/Rilpivirine/Tenofovir
More Detail on Drug Interactions With Emtricitabine/Rilpivirine/TenofovirThe following sections explain in detail the potentially negative reactions that can occur when emtricitabine/rilpivirine/tenofovir is combined with any of the drugs listed above.
Antacids can decrease the absorption of emtricitabine/rilpivirine/tenofovir into the bloodstream, causing it to be less effective. Make sure to take antacid medications at least two hours before or four hours after your dose of emtricitabine/rilpivirine/tenofovir.
Certain Antibiotics or Antifungals
Combining emtricitabine/rilpivirine/tenofovir with certain antibiotics or antifungals may increase the level of emtricitabine/rilpivirine/tenofovir in your blood, and may even decrease the level of some antifungals in your blood. Check with your healthcare provider before taking emtricitabine/rilpivirine/tenofovir with any of these medications.
Certain Seizure Medications
Emtricitabine/rilpivirine/tenofovir should never be combined with carbamazepine, oxcarbazepine, phenobarbital, or phenytoin, as these medications can significantly decrease the effectiveness of emtricitabine/rilpivirine/tenofovir.
Emtricitabine/rilpivirine/tenofovir should never be combined with more than a single dose of dexamethasone, as it can significantly decrease the effectiveness of emtricitabine/rilpivirine/tenofovir. A single, one-time dose of dexamethasone is acceptable.
H2 blockers can decrease the absorption of emtricitabine/rilpivirine/tenofovir, making it less effective. If you absolutely must take an H2 blocker, make sure to take it at least 12 hours before or 4 hours after a dose of emtricitabine/rilpivirine/tenofovir. It is probably not possible to take H2 blockers twice a day while taking emtricitabine/rilpivirine/tenofovir.