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More Medicines That Interfere With Efavirenz

Diltiazem
Efavirenz can decrease the level of diltiazem in your blood, perhaps making it less effective. Your healthcare provider may need to increase your diltiazem dosage to prevent this.
 
Ergot Medications
Efavirenz and ergot medications should not be taken together, due to the risk of life-threatening reactions.
 
Hormonal Contraceptives
Efavirenz can potentially make hormonal contraceptives less effective. Women using hormonal contraceptives should always use an additional reliable method of birth control, such as condoms, while taking efavirenz and for 12 weeks after stopping treatment, since the medication lasts quite awhile in the bloodstream.
 
Maraviroc
Efavirenz can decrease the level of maraviroc in your blood, perhaps making it less effective. Your healthcare provider may need to increase your maraviroc dosage to account for this interaction.
   
Methadone
Efavirenz can decrease the level of methadone in your blood, perhaps making it less effective. Your healthcare provider may need to increase your methadone dosage to prevent this interaction from occurring.
 
Pimozide
Pimozide and efavirenz should not be taken together, due to the risk of serious or life-threatening reactions, such as an irregular heart rhythm (arrhythmia).
 
Protease Inhibitors
Efavirenz may interact with protease inhibitors, either increasing or decreasing the level of the protease inhibitor in your blood, depending on the particular medication. Your healthcare provider may need to adjust the dose of your protease inhibitor to prevent this.
 
Sertraline
Efavirenz can decrease the level of sertraline in your blood, perhaps making it less effective. Your healthcare provider may need to increase your sertraline dosage to prevent this interaction from occurring.

Efavirenz for HIV/AIDS

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