Efavirenz Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when
efavirenz is combined with any of the drugs listed above.
Bepridil
Bepridil and efavirenz should not be taken together, due to the risk of serious or life-threatening reactions, such as an irregular heart rhythm (arrhythmia).
Certain Antibiotics or Antifungals
Combining efavirenz with certain antibiotics or antifungals may increase the risk of
side effects of efavirenz (due to increased blood levels of efavirenz) or decrease the level of the antibiotic or antifungal in the blood (making it less effective). If you take efavirenz with an antibiotic or antifungal medication, your healthcare provider may need to adjust the dose of both of the medications.
Certain Benzodiazepines
Efavirenz can increase the level of certain benzodiazepine medications in the blood, increasing the risk of side effects. With two of these medications (
midazolam and
triazolam), this interaction is so severe that they should never be taken with efavirenz.
Certain Seizure Medications
Taking efavirenz with certain
seizure medications can decrease the level of both efavirenz and the
seizure medication in your blood, making them less effective. Your healthcare provider may need to adjust your dose of these medications to prevent this interaction from occurring.
Diltiazem
Efavirenz can decrease the level of
diltiazem in your blood, perhaps making it less effective. Your healthcare provider may need to increase your
diltiazem dosage to prevent this.
Ergot Medications
Efavirenz and ergot medications should not be taken together, due to the risk of life-threatening reactions.
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