Drug Interactions With Efavirenz, Emtricitabine, and Tenofovir

Hormonal contraceptives, protease inhibitors, and methadone are some of the medications that have been shown to cause drug interactions with efavirenz, emtricitabine, and tenofovir. These interactions can lead to increased blood levels of the HIV drug, which could increase your risk for developing potentially serious side effects. Other medications that may cause drug interactions with efavirenz, emtricitabine, and tenofovir include diltiazem, valacyclovir, and warfarin.

Drug Interactions With Efavirenz, Emtricitabine, and Tenofovir: An Overview

 Efavirenz, emtricitabine, and tenofovir disoproxil fumarate (Atripla™) can potentially interact with several other medicines. Some of the medicines that may lead to efavirenz, emtricitabine, and tenofovir drug interactions include:
 
 
 
  • Certain benzodiazepine medications, such as:
 
 
  • Certain seizure medications, such as:
 
 
 
    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergotamine (Bellamine S®, Cafergot®, Ergomar®)
    • Pergolide (Permax®)
 
 
 
  • Pimozide (Orap®)
  • Protease inhibitors, such as:
 
 
 

 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
 
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