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Side Effects of Didanosine

During extensive clinical trials studying the side effects of didanosine, diarrhea was reported the most often. Other common side effects included nerve problems and stomach pain. In most cases, the side effects of didanosine are minor and can easily be treated you or your healthcare provider. However, notify your healthcare provider immediately if you develop more serious side effects, such as vision changes or signs of an allergic reaction.

Side Effects of Didanosine: An Introduction

As with any medicine, side effects are possible with didanosine (Videx®). However, not everyone who takes the medication will experience side effects. In fact, most people tolerate it quite well. When side effects do occur, in most cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with didanosine. Your healthcare provider can discuss a more complete list of didanosine side effects with you.)

Side Effects of Didanosine to Report

There are a number of side effects with didanosine that you should report to your healthcare provider. These include, but are not limited to:


    • A tender or swollen abdomen
    • Nausea and vomiting
    • Fever
    • A rapid heart rate (tachycardia)
    • Rapid breathing 


  • Symptoms of lactic acidosis (too much lactic acid in the blood), such as:


    • Feeling tired or weak
    • Muscle pain
    • Trouble breathing
    • Feeling cold
    • Cold or blue hands and feet
    • Dizziness or lightheadedness
    • A slow or irregular heartbeat
    • Persistent nausea, vomiting, and abdominal pain (stomach pain)
    • Shortness of breath
    • An enlarged or tender liver
    • Weight loss


  • Signs of liver damage, such as yellowing of the whites of the eyes or skin (jaundice) or upper right abdominal (stomach) pain
  • Changes in the distribution of fat on your body (such as a "buffalo hump")
  • Any vision changes
  • Signs of an allergic reaction, including an unexplained rash, hives, itching, unexplained swelling, wheezing, or difficulty breathing or swallowing.

Didanosine -- HIV Drug Information

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