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Medications That Interfere With Depo-Provera

Griseofulvin may decrease the effectiveness of combination birth control pills (pills that contain estrogen and progestin). Although it is unknown if griseofulvin also affects Depo-Provera, you may want to use another form of birth control if you are taking griseofulvin and also receiving Depo-Provera injections.
Protease Inhibitors
Protease inhibitors can increase or decrease the level of Depo-Provera in the bloodstream, which could increase the risk for side effects or make the medication less effective. Check with your healthcare provider before combining Depo-Provera with a protease inhibitor.
Retinoids may decrease the effectiveness of progestin-only birth control pills. It is unknown if retinoids affect Depo-Provera in the same way. If you are using Depo-Provera as a form of contraception, talk to your healthcare provider about this potential interaction. You may need to use a different birth control method.
Tranexamic Acid
Both tranexamic acid and hormonal contraceptives (including Depo-Provera) can increase the risk for blood clots. Taking these medications together may increase this risk even more than using either medicine alone. Talk to your healthcare provider about this potential interaction before taking these medications together.

Final Thoughts

It is possible that not all drug interactions with Depo-Provera were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.
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