Medications That Interfere With Depo-Provera
CYP 3A4 Inducer Medications
The liver breaks down the hormones in Depo-Provera using enzymes known as CYP 3A4 enzymes. Certain medications known as CYP 3A4 inducers can increase the activity of these enzymes. Combining Depo-Provera with one of these CYP 3A4 inducers may decrease the level of Depo-Provera in your bloodstream, possibly making it less effective. If you are taking Depo-Provera as a contraceptive, talk to your healthcare provider about this interaction. You may need to use a different birth control method.
Griseofulvin may decrease the effectiveness of combination birth control pills (pills that contain estrogen and progestin). Although it is unknown if griseofulvin also affects Depo-Provera, you may want to use another form of birth control if you are taking griseofulvin and also receiving Depo-Provera injections.
Protease inhibitors can increase or decrease the level of Depo-Provera in the bloodstream, which could increase the risk for side effects or make the medication less effective. Check with your healthcare provider before combining Depo-Provera with a protease inhibitor.
Retinoids may decrease the effectiveness of progestin-only birth control pills. It is unknown if retinoids affect Depo-Provera in the same way. If you are using Depo-Provera as a form of contraception, talk to your healthcare provider about this potential interaction. You may need to use a different birth control method.
Both tranexamic acid and hormonal contraceptives (including Depo-Provera) can increase the risk for blood clots. Taking these medications together may increase this risk even more than using either medicine alone. Talk to your healthcare provider about this potential interaction before taking these medications together.