Depo-Provera and Weight Gain
If you are using Depo-Provera® (medroxyprogesterone intramuscular injection), be aware that weight gain is a possible side effect of the drug. This prescription medication is approved for pregnancy prevention and for relieving symptoms of kidney and endometrial cancer.
In clinical studies, up to 37.7 percent of people noticed weight gain while using Depo-Provera. These studies also showed that two-thirds of women gained at least five pounds in the first year of use. The average weight gain was eight pounds after two years of use.
(For more information, click Depo-Provera Warnings and Precautions. This article also covers potentially serious reactions and discusses who should avoid the drug entirely.)