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Precautions and Warnings With Delavirdine

There are numerous precautions and warnings with delavirdine to be aware of before starting treatment. It is important to know that the medication may change body fat distribution, cause skin rashes, and interact with certain medications. Precautions and warnings with delavirdine also apply to people with low stomach acid production (known medically as achlorhydria) or any allergies.

Delavirdine: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking delavirdine mesylate (Rescriptor®) if you have:
 
  • Achlorhydria (low stomach acid production)
  • Any allergies, including allergies to food, dyes, or preservatives.
     
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
     
You should also be sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 

Specific Precautions and Warnings With Delavirdine

Warnings and precautions to be aware of prior to taking delavirdine include the following:
 
  • Delavirdine can interact with several different medications. Many of these interactions are quite dangerous. Make sure that all of your healthcare providers know that you are taking delavirdine, and make sure to check with them before starting or stopping any new medications (see Drug Interactions With Delavirdine).
     
  • Stomach acid is necessary for the absorption of delavirdine into the bloodstream. Talk with your healthcare provider if you have a condition or take a medication that reduces the acid in your stomach.
     
  • Delavirdine often causes harmless skin rashes. However, if you have a rash with blisters, loss of skin, a fever, or mouth sores, be sure to tell your healthcare provider immediately, as this may be a sign of a life-threatening reaction to the medication.
     
  • Delavirdine can change the distribution of fat on your body. You may gain fat in areas that are not typical for you, such as in the abdomen or at the back of the neck (a "buffalo hump"), and may lose weight in other areas.
     
  • Delavirdine is not a cure for HIV or AIDS. If you have HIV or AIDS, you should always use safer sex practices, whether or not you are taking medications.
     
  • As with all HIV medications, it is important that you take delavirdine exactly as prescribed. Missing doses may increase the chance of the virus becoming resistant to HIV medications.
     
  • Delavirdine is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Rescriptor and Pregnancy).
 
  • It is not known whether delavirdine passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Rescriptor and Breastfeeding). It is important to understand that the HIV virus can be transmitted through breast milk and that breastfeeding is usually not recommended in women with HIV or AIDS.
     

Delavirdine Drug Information

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