Drug Interactions With Darunavir

Several medications can cause negative drug interactions with darunavir, including warfarin, fluticasone, certain statin cholesterol medicines, and calcium channel blockers. When drug interactions occur, the effectiveness of the medications can be decreased and your risk for developing serious side effects can be increased. Make sure to tell your healthcare provider about all other medicines you are taking to help prevent drug interactions with darunavir.

 

Drug Interactions With Darunavir: An Introduction

Darunavir ethanolate (Prezista™) can potentially interact with several other medicines. Some of the medicines that may lead to darunavir drug interactions include:
 
 
 
  • Certain antibiotics and antifungal medications, such as:
 
    • Clarithromycin (Biaxin®)
    • Ketoconazole (Nizoral®)
    • Itraconazole (Sporanox®)
    • Rifabutin (Mycobutin®)
    • Rifampin (Rifadin®)
    • Voriconazole (Vfend®)
 
  • Certain arrhythmia medications, such as:
 
    • Amiodarone (Cordarone®)
    • Lidocaine
    • Quinidine
 
  • Certain benzodiazepines, such as:
 
 
  • Certain other protease inhibitors, such as:
 
 
 
 
  • Ergot medications, such as:
 
    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergonovine
    • Ergotamine (Bellamine S®, Cafergot®, Ergomar®)
    • Methylergonovine (Methergine®)
    • Pergolide (Permax®)
 
  • Fluticasone (Flonase®, Flovent®, Veramyst®) or combination medications that contain fluticasone (Advair®)
  • Immune-suppressing medications, such as:
 
    • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
    • Sirolimus (Rapamune®)
    • Tacrolimus (Prograf®)
 
 
 
 
 
(Drug Interactions With Darunavir Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;