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Will My Medicines Interact With Darunavir?

Some Seizure Medications
Darunavir should never be used in combination with carbamazepine, phenobarbital, or phenytoin, as these medications may make darunavir less effective.
 
Some Statin Medications
Darunavir should never be combined with lovastatin or simvastatin, due to the risk of dangerous side effects. Since darunavir may increase the level of atorvastatin, rosuvastatin, or pravastatin in your blood, your healthcare provider may recommend a lower dosage of these medications.
 
St. John's Wort
Because St. John's wort can greatly reduce the level of darunavir in your blood, darunavir should never be taken with St. John's wort.
 
Trazodone (Desyrel) or Trazodone ER (Oleptro) 
Darunavir can increase the level of trazodone in your blood. Check with your healthcare provider before taking these medications together.
 
Warfarin
Darunavir can decrease the level of warfarin in your blood, potentially increasing your risk of blood clots. Your healthcare provider may need to monitor you more closely and adjust your warfarin dosage as necessary.
 

Final Thoughts on Drug Interactions With Darunavir

It is possible that not all drug interactions with darunavir were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific drug interactions that may apply to you.
 

Darunavir Drug Information

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