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Drug Combinations With Darunavir to Avoid

Methadone
Darunavir can decrease the level of methadone in your blood, perhaps making it less effective. Your healthcare provider may need to increase your methadone dosage to prevent this.
 
Oral Contraceptives
Darunavir may make oral contraceptives less effective. You should use a non-hormonal method of contraception (such as condoms) while taking darunavir.
 
Paroxetine
Darunavir can decrease the level of paroxetine in your blood. Your healthcare provider may need to increase your paroxetine dosage to prevent this interaction from occurring.
 
Phosphodiesterase Type 5 Inhibitors (PDE5 Inhibitors)
Darunavir can increase the level of PDE5 inhibitors in your blood, increasing your risk of side effects. You should not take more than 25 mg of sildenafil (for erectile dysfunction treatment) in 48 hours, 10 mg of tadalafil (for erectile dysfunction treatment) in 72 hours, or 2.5 mg of vardenafil in 72 hours while taking darunavir.
 
At this time, it is recommended that if you take sildenafil for the purpose of treating pulmonary arterial hypertension, you should not take darunavir. When combining tadalafil for the purpose of treating pulmonary arterial hypertension with darunavir, the initial tadalafil dosage should be 20 mg once daily and may be adjusted up to 40 mg once daily as necessary and tolerated.
  
Pimozide
Pimozide and darunavir should not be taken together, due to the risk of dangerous reactions.
 
Salmeterol
Combining salmeterol with darunavir may increase the risk of serious side effects of salmeterol, especially heart problems. Check with your healthcare provider before combining such medications. In general, these medications should not be combined.
  
Sertraline
Darunavir can decrease the level of sertraline in your blood. Your healthcare provider may need to increase your sertraline dosage to prevent this interaction from occurring.

Darunavir Drug Information

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