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Understanding How Darunavir Works and What to Tell Your Doctor

Darunavir: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking darunavir if you have:
 
Also, let your healthcare provider know if you are:
 
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 
(Click Precautions and Warnings With Darunavir to learn more, including information on who should not take the drug.)
 

How Does Darunavir Work?

Darunavir is part of a group of HIV medications known as protease inhibitors. These medicines work by blocking a process that the HIV virus needs in order to multiply.
 
HIV (human immunodeficiency virus) is the virus that causes AIDS. Like other viruses, it must use a person's own cells to reproduce. Once inside an infected cell, the HIV virus uses the cell to make DNA, which enables it to make new HIV viruses that can spread to other cells. The DNA is made in long strands that must be clipped into shorter, usable strands using enzymes called proteases.
 
Darunavir is a protease inhibitor, which means that it stops protease enzymes from clipping DNA into short strands. Since the long, unclipped DNA strands cannot be used to make new viruses, this helps stop the spread of HIV to other uninfected cells. Darunavir is not a cure for HIV or AIDS, however. It can help stop HIV from infecting healthy cells in the body, but it does not help cells that have already been infected with the virus.
 
Darunavir is always used in combination with ritonavir. Ritonavir increases the level of darunavir in the blood, helping it to work better. This is known as "boosting." Ritonavir is used to boost several different HIV medications.
 

Darunavir Drug Information

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