For the treatment of HIV and AIDS in adults, the recommended darunavir dosage is 600 mg, taken twice a day with food and with 100 mg of ritonavir. Taking the medication without food or ritonavir will decrease the level of darunavir in your blood, making it less effective. Therefore, to help ensure the effectiveness of darunavir, dosing guidelines must be followed carefully.
The dose of darunavir ethanolate (Prezista™) that your healthcare provider recommends will vary, depending on a number of factors, including:
- Your age
- Your weight (in children)
- Whether or not you have taken other HIV medications before
- Other medical conditions you may have
- Other medications you may be taking.
As always, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
Darunavir Dosing for AdultsDarunavir is always combined with ritonavir (Norvir®), another HIV medication that increases the level of darunavir in the blood and helps it work better.
The recommended dose of darunavir for treating adults with HIV or AIDS who have already taken HIV medications before ("treatment-experienced" individuals) is darunavir 600 mg (two 300-mg tablets) twice daily with food, taken with ritonavir 100 mg twice daily. Such individuals might be able to take a once-a-day dosage (800 mg once daily with food, taken with ritonavir 100 mg once daily) if tests show that their version of HIV is not resistant to darunavir.
For adults who have not taken HIV medications before ("treatment-naïve" individuals), the recommended darunavir dosage is 800 mg (two darunavir 400 mg tablets) taken once a day with food, combined with ritonavir once daily.