Drugs That React With Atazanavir
Atazanavir Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when atazanavir is combined with any of the drugs listed above.
Atazanavir should not be combined with alfuzosin, as this may increase the amount of alfuzosin in the blood to dangerous levels.
Antacids may decrease the level of atazanavir in your blood. In order to avoid this interaction, be sure to take atazanavir at least two hours before or one hour after taking an antacid medication.
Atazanavir may increase the level of bosentan in your blood. Your healthcare provider may need to lower your bosentan dosage while you are taking atazanavir.
Atazanavir may increase the level of buprenorphine in the blood, perhaps increasing the risk of side effects of buprenorphine. In addition, buprenorphine may decrease the level of atazanavir in the blood, perhaps making it less effective. If you take atazanavir without ritonavir (Norvir®), you should not take buprenorphine. If you take atazanavir with ritonavir (which is used to boost the level of atazanavir in the blood), this interaction is probably unimportant.
Certain Antibiotics or Antifungals
Combining atazanavir with certain antibiotics or antifungals may increase or decrease the level of both atazanavir and the antibiotic or antifungal in your blood. Check with your healthcare provider before taking atazanavir with any of these medications. It should never be combined with rifampin, since rifampin may make atazanavir less effective.
Certain Arrhythmia Medications
Atazanavir may increase the level of certain arrhythmia medications in your blood, potentially increasing the risk of dangerous side effects. Talk with your healthcare provider before taking these medications together.