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Side Effects of Amprenavir

Common side effects of amprenavir may include nausea, headaches, and fatigue. There are also a number of potentially serious side effects that should be reported to a healthcare provider right away, such as signs of an allergic reaction, unusual bleeding or bruising, and depression. In most cases, however, amprenavir side effects are minor and can easily be treated by you or your healthcare provider.

Side Effects of Amprenavir: An Introduction

As with any medicine, side effects are possible with amprenavir (Agenerase®). However, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider.
 
(This article covers many, but not all, of the possible side effects with amprenavir. Your healthcare provider can discuss a more complete list of amprenavir side effects with you.)
 
Amprenavir is no longer available in the United States. The manufacturer stopped making it due to low demand, since it has been largely replaced by fosamprenavir (Lexiva®), a similar medication.
 

Side Effects of Amprenavir to Report

Some side effects with amprenavir, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
 
  • Depression
  • Signs of poisoning from propylene glycol (an inactive ingredient in amprenavir oral solution), such as:
 
    • Seizures
    • A rapid heart rate (tachycardia)
    • Feeling tired or weak
    • Muscle pain
    • Trouble breathing
    • Abdominal pain (stomach pain)
    • Feeling cold
    • Dizziness or lightheadedness
    • Drunken appearance or behavior
 
  • Signs of liver damage, such as:
 
    • Fatigue or a general ill feeling (malaise)
    • Loss of appetite
    • Nausea
    • Yellowing of the whites of the eyes or skin (jaundice)
    • Tenderness near the liver (the upper-right abdomen)
    • Pale stools
 
  • High blood sugar (hyperglycemia)
  • Unusual or unexplained bleeding
  • Changes in the distribution of fat on your body (such as a "buffalo hump")
  • Signs of an allergic reaction, such as:
 
    • A rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.
 

Amprenavir Drug Information

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