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Specific Safety Issues With Amprenavir

Specific Precautions and Warnings With Amprenavir

Warnings and precautions to be aware of prior to taking amprenavir include the following:
  • Amprenavir oral solution (but not capsules) contains propylene glycol, which can be toxic if taken in large quantities. Due to these risks, amprenavir oral solution should never be taken by children under four years old, pregnant women, or people who have liver or kidney failure. Also, people who take amprenavir oral solution should not drink alcohol.
  • Children who take amprenavir oral solution should be switched to amprenavir capsules as soon as they are able to swallow the capsules. It is important to note that these two products are not equivalent on a mg-per-mg basis (in other words, 50 mg of amprenavir solution is not equivalent to a 50-mg amprenavir capsule).
  • Amprenavir can destroy red blood cells (this is known as hemolytic anemia).
  • The medication frequently causes skin rashes. Most often, these rashes are harmless, although sometimes they can be quite dangerous. Let your healthcare provider know if you develop a rash while taking amprenavir.
  • Amprenavir is a sulfonamide (a "sulfa" drug). Therefore, if you have a sulfa allergy, do not take amprenavir without first talking to your healthcare provider.
  • The liver helps to remove amprenavir from the blood. Therefore, if you have liver disease, amprenavir can make it worse. Make sure to tell your healthcare provider if you already have liver disease or liver damage prior to taking the drug.
  • Amprenavir can cause high blood sugar (hyperglycemia). This can cause problems for people who have diabetes, or it can even cause diabetes in individuals who are at risk for the condition.
  • There have been reports of bleeding due to protease inhibitors (such as amprenavir) in people who have hemophilia. Be sure your healthcare provider knows if you have this condition.
  • Amprenavir can increase triglyceride levels. Your healthcare provider should regularly check your triglyceride and cholesterol levels while you are taking the medication.
  • The medication can change the distribution of fat on your body. You may gain fat in areas that are not typical for you, such as in the abdomen or at the back of the neck (a "buffalo hump"), and you may lose weight in other areas.
  • Amprenavir is not a cure for HIV or AIDS. If you have HIV or AIDS, you should always use safer sex practices, whether or not you are taking medications.
  • As with all HIV medications, it is important that you take amprenavir exactly as prescribed. Missing doses may increase the chance of the virus becoming resistant to HIV medications.
  • Amprenavir can interact with a number of different medications (see Drug Interactions With Amprenavir).
  • Amprenavir is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Agenerase and Pregnancy). Amprenavir oral solution (but not capsules) should never be taken during pregnancy.
  • It is not known if amprenavir passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Agenerase and Breastfeeding). It is important to understand that the HIV virus can be transmitted through breast milk and that breastfeeding is usually not recommended in women who have HIV or AIDS.

Amprenavir Drug Information

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