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Drug Interactions With Amprenavir

Alcohol, antacids, and certain antibiotics are among the substances that may cause drug interactions with amprenavir. These interactions can increase the level of amprenavir in your blood, possibly increasing your risk of side effects. Or, the levels of the medications in your blood may decrease, reducing the drugs' effectiveness. Talk to your healthcare provider about any possible drug interactions with amprenavir that may apply to you.

Drug Interactions With Amprenavir: An Overview

Amprenavir is no longer available in the United States. The manufacturer stopped making it due to low demand, since it has been largely replaced by fosamprenavir (Lexiva®), a similar medication.


Amprenavir (Agenerase®) can potentially interact with several other medicines. Some of the medicines that may lead to amprenavir drug interactions include:
  • Alcohol
  • Antacids
  • Arrhythmia medications
  • Certain antibiotics and antifungal medications, such as:
    • Ketoconazole (Nizoral®)
    • Itraconazole (Sporanox®)
    • Rifabutin (Mycobutin®)
    • Rifampin (Rifadin®)
  • Certain benzodiazepines, such as:
    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergonovine
    • Ergotamine (Bellamine S®, Cafergot®, Ergomar®)
    • Methylergonovine (Methergine®)
    • Pergolide (Permax®)


  • Phosphodiesterase type 5 inhibitors (PDE5 inhibitors), including:



Amprenavir Drug Information

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