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Will My Medicines Interact With Amprenavir?

St. John's Wort
Because St. John's wort can greatly reduce the level of amprenavir in your blood, these medications should never be taken together.
Trazodone (Desyrel) or Trazodone ER (Oleptro) 
Amprenavir can increase the level of trazodone in your blood. Check with your healthcare provider before taking these medications together.
Tricyclic Antidepressants
Amprenavir can increase the level of tricyclic antidepressants in your blood, possibly increasing the risk of dangerous side effects. Your healthcare provider should monitor the level of tricyclic antidepressant in your blood and adjust your dose as necessary.
Vitamin E
Amprenavir contains a high dose of vitamin E. Therefore, you should not take any additional vitamin E (in supplements or vitamins) while taking amprenavir.
Amprenavir can interact with warfarin. Your healthcare provider may need to monitor you more closely and adjust your warfarin dosage as necessary.

Final Thoughts on Drug Interactions With Amprenavir

It is possible that not all drug interactions with amprenavir were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific drug interactions that may apply to you.

Amprenavir Drug Information

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