Amprenavir Dosing

The amprenavir dosage for treating adults with HIV or AIDS is 1200 mg twice daily. Dosing recommendations for children are primarily based on weight. Amprenavir solution should only be taken by those who cannot swallow the capsules. Other factors that may affect your amprenavir dosage include other medical conditions you may have and other medications you are taking.

 

Amprenavir Dosing: An Introduction

The dose of amprenavir (Agenerase®) that your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • Your age
  • Your weight (for children)
  • Other medical conditions you may have
  • Other medications you may be currently taking.
     
As always, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
 

Amprenavir Dosing for Adults

The recommended dose of amprenavir for treating adults with HIV or AIDS is amprenavir 1200 mg twice daily. Unfortunately, amprenavir capsules only come in one strength (50 mg), which means that the recommended dose for adults is 24 capsules twice daily. If amprenavir is combined with Norvir® (ritonavir), then either of the following dosing regimens is recommended:
 
  • Amprenavir 1200 mg (24 capsules) once daily, plus Norvir 200 mg once daily
  • Amprenavir 600 mg (12 capsules), plus Norvir 100 mg twice daily.
     
Adults should not take amprenavir solution. It contains propylene glycol, which can be dangerous in large amounts, and anyone who is able to take the capsules should not take the solution. Pregnant women and people with liver or kidney failure should never take amprenavir solution.
 

Amprenavir Dosing for Children

Your child's healthcare provider will calculate the amprenavir dose based on your child's age and weight. Because amprenavir oral solution contains propylene glycol, which is dangerous in large amounts, children should be switched from the solution to capsules as soon as they can swallow capsules. For children, amprenavir is taken two or three times daily.
 
It is important to note that amprenavir solution and amprenavir capsules are not equivalent on a mg-per-mg basis. In other words, 50 mg of amprenavir solution is not equivalent to a 50-mg amprenavir capsule.
 
(Amprenavir Dosing Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;