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Drug Interactions With Abacavir/Lamivudine

Some of the medications that may cause drug interactions with abacavir/lamivudine include methadone, valganciclovir, and ribavirin. These negative interactions could increase your risk of side effects and affect the level of abacavir/lamivudine in your blood. To help prevent abacavir/lamivudine drug interactions, be sure to tell your healthcare provider about all other medicines you are taking.

Abacavir/Lamivudine Drug Interactions: An Introduction

Abacavir/lamivudine (Epzicom™) can potentially interact with several other medicines. Some of these medicines that may lead to abacavir/lamivudine interactions include:
  • Alcohol
  • Ganciclovir (Cytovene®)
  • Interferon medications, such as:



  • Methadone (Dolophine®, Methadose®)
  • Ribavirin (Copegus®, Rebetol®, Ribasphere®, Virazole®)
  • Trimethoprim and sulfamethoxazole (Bactrim®, Septra®)
  • Valganciclovir (Valcyte™)
  • Zalcitabine (Hivid®).

Abacavir/Lamivudine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when abacavir/lamivudine is combined with any of the drugs listed above.

Abacavir/Lamivudine for HIV/AIDS

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