Drug Interactions With Abacavir/Lamivudine/Zidovudine

Abacavir/Lamivudine/Zidovudine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when abacavir/lamivudine/zidovudine is combined with any of the drugs listed above.
 
Alcohol
Drinking alcoholic beverages can increase the level of abacavir (one of the components of abacavir/lamivudine/zidovudine) in your blood, perhaps increasing your risk of side effects. It may be a good idea to avoid alcohol while taking abacavir/lamivudine/zidovudine.
 
Atovaquone (Mepron)
Taking atovaquone with abacavir/lamivudine/zidovudine may increase the level of abacavir/lamivudine/zidovudine in your blood, increasing your risk of side effects. Talk with your healthcare provider before taking these medications together.
 
Doxorubicin (Adriamycin, Doxil, Evacet)
Doxorubicin can make abacavir/lamivudine/zidovudine less effective and may also increase the risk of abacavir/lamivudine/zidovudine side effects. In general, these medications should not be taken together.
 
Fluconazole (Diflucan)
Fluconazole may increase the level of abacavir/lamivudine/zidovudine in your blood, increasing your risk of side effects. Talk with your healthcare provider before using these medications. You may need to be monitored more closely.
 
Ganciclovir (Cytovene)
Combining ganciclovir with abacavir/lamivudine/zidovudine may increase your risk of abacavir/lamivudine/zidovudine side effects, particularly side effects that affect blood cells. Your healthcare provider may need to monitor your blood counts very closely.
 
Interferon Medications
Combining an interferon with abacavir/lamivudine/zidovudine may increase your risk of abacavir/lamivudine/zidovudine side effects, particularly side effects that affect blood cells. Your healthcare provider may need to monitor your blood counts very closely.
(Drug Interactions With Abacavir/Lamivudine/Zidovudine Continued: Page 3)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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